化合物BAY 60-6583 T14506

Product Introduction
Bioactivity


英文名: BAY 60-6583

描述: BAY 60-6583 是一种强效、高亲和力的腺苷 A2B 受体激动剂（EC50 = 3 nM），对A2B 受体的亲和力超过对 A1、A2A 和 A3 受体的亲和力。BAY 60-6583 在心肌缺血模型中具有心脏保护作用。BAY 60-6583 与小鼠、兔子和狗 A2BAR 的结合 Ki 值分别为 750 nM、340 nM 和 330 nM。

体外活性: BAY 60-6583(0-10 μM) exhibits the maximum agonist effect of BAY 60-6583 in the absence of siRNA is 68 %.[3] BAY 60-6583 (5 μM; 24 h) induces a rise in cell accumulation within the G1 phase while concurrently reducing the G2/M phase in RAW264.7 preosteoclasts. Additionally, under the same conditions, BAY 60-6583 specifically impedes Akt activation triggered by M-CSF, with no discernible impact on M-CSF-induced ERK1/2 activation in RAW264.7 preosteoclasts.[4]

体内活性: BAY 60-6583 (100 mg/kg; intravenous injection; rabbit) administered just before reperfusion, diminishes the infarction area in ischemic rabbit hearts.[1]BAY 60-6583 (2 mg/kg; intravenous injection; mice) attenuates LPS-induced lung injury, pre-treatment with this compound can significantly decrease LPS-increased, IL-6 levels in WT mice.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90.0 mg/mL (237.2 mM)


关键字: BAY 606583 | BAY 60-6583 | BAY 60 6583

相关产品: Proxyphylline | SCH 58261 | Adenosine receptor antagonist 4 | 2'-MeCCPA | A2B receptor antagonist 2 | PSB 0777 ammonium hydrate | Reversine | MRS-1706 | DPTN dihydrochloride | MIPS521

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Bioactive Compound Library

化合物BAY 60-6583 T14506信息由TargetMol中国为您提供，如您想了解更多关于化合物BAY 60-6583 T14506报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途