化合物Ciliobrevin D T14965

Product Introduction
Bioactivity


英文名: Ciliobrevin D

描述: Ciliobrevin D 是细胞渗透性，可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。

体外活性: Ciliobrevin D reversibly inhibits melanosome aggregation, however, the non-cilia-disrupting derivative had no discernible effect at comparable doses. Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels and it similarly abrogates the movement of peroxisomes in Drosophila S2 cells[1].

体内活性: In the testis in vivo, Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D perturbs spermatogenesis. The use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5 mg/mL (12.73 mM)


关键字: inhibit | melanosome | spindles | cytoplasmic | Ciliobrevin D | γ-tubulin | Inhibitor | dynein | ATPases | Hedgehog | peroxisomes | aggregation

相关产品: 3-Hydroxybakuchiol | Leminoprazole | Rostafuroxin | Ginsenoside Rb1 | Zeorin | Tirofiban hydrochloride monohydrate | Dicirenone | Tegoprazan | Brefeldin A | Deslanoside

相关库: Ion Channel Inhibitor Library | Anti-Prostate Cancer Compound Library | Microtubule-Targeted Compound Library | Neuronal Differentiation Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | GPCR Compound Library | Reprogramming Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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