化合物FN-1501 T15335
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 1429515-59-2 | ¥2,490.00 | 询底价 |
100 mg | 1429515-59-2 | ¥8,370.00 | 询底价 |
5 mg | 1429515-59-2 | ¥1,570.00 | 询底价 |
1 mL | 1429515-59-2 | ¥1,730.00 | 询底价 |
25 mg | 1429515-59-2 | ¥4,260.00 | 询底价 |
50 mg | 1429515-59-2 | ¥6,070.00 | 询底价 |
1 mg | 1429515-59-2 | ¥663.00 | 询底价 |
Product Introduction
Bioactivity
英文名: FN-1501
描述: FN-1501 是一种有效的 FLT3 和 CDK 抑制剂,具有抗肿瘤的活性,对 CDK2/cyclin A、CDK4/cyclin D1、CDK6/cyclin D1 和 FLT3 的 IC50值分别为 2.47、0.85、1.96 和 0.28 nM。
体外活性: FN-1501 displays potent inhibitory activity against several tumor cells, such as MGC803, RS4;11, MCF-7, HCT-116, and NCI-H82 (GI50s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively)[1].
体内活性: FN-1501 shows potent antitumor activity and it also shows little cytotoxicity on normal lymphocyte cells (LD50: 185.67 mg/kg in ICR mice). FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and obviously inhibits the growth of tumors in MV4-11-cell-inoculated-xenograft mice[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (104.29 mM)
关键字: FLT3 | Fms like tyrosine kinase 3 | Cluster of differentiation antigen 135 | CD135 | Cyclin dependent kinase | CDK | FN1501 | inhibit | Inhibitor | FN 1501 | FN-1501
相关产品: Dovitinib Dilactic Acid | Tesevatinib | Sunitinib Malate | TCS 359 | Sunitinib | JI6 | AEE788 | VX-11e | 7BIO | Tandutinib
相关库: Drug Repurposing Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途