呋咯地辛 T15337

Product Introduction
Bioactivity


英文名: Forodesine

描述: Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could induce apoptosis in leukemic cells by increasing the dGTP levels.

体外活性: Forodesine (10-30?μM; 24 and 48 hours; RPMI-8226, MOLT-4, and 5T33MM cells) has no effect on the MM cells at 24 hours, while it could decrease the percentage of living cells in the MOLT-4 cells with 40%. Forodesine (10-30?μM; 24 and 48 hours; RPMI-8226, MOLT-4, and 5T33MM cells) treatment is partially inhibition of proliferation [1]. Forodesine inhibits human lymphocyte proliferation activated by various agents such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50s < 0.1-0.38 μM), in the presence of 2'-deoxyguanosine (dGuo, 3-10 μM) [2].

体内活性: Forodesine has excellent oral bioavailability (63%) in mice. Forodesine(single dose of 10 mg/kg; in mice ) treatment, elevates dGuo to approximately 5 μM. Forodesine is effective in prolonging the life span 2-fold or more, in the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model [2].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Forodesine | BCX 1777 | BCX1777

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途