化合物GANT 58 T15370

Product Introduction
Bioactivity


英文名: GANT 58

描述: GANT 58 (NSC-75503) 是GLI 拮抗剂，能够抑制 GLI1 诱导的转录，其IC50=5 μM。

体外活性: GANT58 is a downstream inhibitor of Hh signaling and it also is an indeed inhibitor of Hh signaling downstream of Smo and Sufu. GANT58 potently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth using human prostate cancer cells harboring downstream activation of the Hh pathway[1]. GANT58 has been shown to inhibit transcriptional activation by GLI1 (as well as by the other GLI species) and it has been shown to inhibit GLI transactivation[2]. GANT58 mainly acts at the nuclear level because transcription induced by GLI1 with a mutated nuclear export signal is still blocked.

体内活性: Nude mice are treated with every second-day s.c. injections at a concentration of 50 mg/kg of cyclopamine, GANT61, GANT58, or solvent only (n=4-5 for each group). Although mice treated with these compounds showed no such signs of toxicity, this protocol is also introduced for the GANTs to be able to compare all compounds. All injections are done 2-3 cm away from the tumors. Suppression of tumor cell growth is observed for all compounds, during an 18-day treatment period. Treatment with cyclopamine or GANT58 results in the inhibition of additional xenograft growth and limited the increase in tumor size[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 9.09 mg/mL (23.16 mM)


关键字: inhibit | GANT 58 | Inhibitor | GANT58 | GANT-58 | Gli | NSC75503 | NSC-75503

相关产品: MRT-10 | SAG | Cyclopamine | RU-SKI 43 | CUR61414 | HPI 1 | Purmorphamine | SAG hydrochloride (912545-86-9(free base)) | Triparanol | BMS-833923

相关库: Anti-Prostate Cancer Compound Library | Wnt/Hedgehog/Notch Compound Library | Neuronal Differentiation Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Osteogenesis Compound Library | Inhibitor Library | GPCR Compound Library | Reprogramming Compound Library | NO PAINS Compound Library

化合物GANT 58 T15370信息由TargetMol中国为您提供，如您想了解更多关于化合物GANT 58 T15370报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途