盐酸萘替芬 T1543
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 65473-14-5 | ¥838.00 | 询底价 |
1 g | 65473-14-5 | ¥1,390.00 | 询底价 |
50 mg | 65473-14-5 | ¥247.00 | 询底价 |
100 mg | 65473-14-5 | ¥348.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Naftifine hydrochloride
描述: Naftifine hydrochloride (Naftifine HCl) 是一种抗生素。它具有抗真菌活性,对皮肤真菌、曲霉、Sporothrix schenckii、假丝酵母属的酵母有抑制作用。
体外活性: Naftifine exhibits an interesting in vitro spectrum of activity against dermatophytes (38 strains; minimal inhibitory concentration (MIC) range 0.1 to 0.2 mg/mL), aspergilli (6 strains; MIC range, 0.8 to 12.5 mg/mL), Sporothrix schenckii (2 strains; MICs, 0.8 and 1.5 mg/mL), and yeasts of the genus Candida (77 strains; MIC range, 1.5 to greater than 100 mg/mL). [1] The MIC of naftifine for C. albicans Δ63 is 100 mg/L in Sabouraud medium (initial pH 6.5). Naftifine (50 mg/L) gives greater than 99% inhibition of sterol biosynthesis both in whole cells and in cell extracts of C. albicans. The primary action of naftifine appears to be the blocking of fungal squalene epoxidation. [2]
体内活性: Naftifine HCl 2% cream results in clinical cure rate and clinical success rate of 33% and 84% after treatment for 4 weeks, and week 2 efficacy response rates in Naftifine HCl 2% subjects are all lower than at week 4 but are significantly higher than week 2 vehicle-treated counterparts. [3] Naftifine causes interruption of fungal ergosterol synthesis and accumulation of squalene in fungal organisms. Naftifine also has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine has shown good efficacy and safety for a variety of conditions and is a useful treatment that provides both antifungal action and relief of inflammatory signs and symptoms. Few adverse events have been noted with naftifine use, the most frequent being mild and transient burning, stinging, or itching in the application area. [4]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 8 mg/mL (24.7 mM)
关键字: Naftifine Hydrochloride | tinea | corporis | pedis | cruris | Naftifine hydrochloride | dermatophytes | Antibiotic | inhibit | Naftifine | Fungal | Inhibitor
相关产品: SAG | CUR61414 hydrochloride | HPI 1 | Taladegib | Vismodegib | GANT 61 | SMO-IN-2 | Ciliobrevin D | Jervine | MK-4101
相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | GPCR Compound Library | Anti-Cancer Approved Drug Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途