化合物 T15467 T15467
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 6754-13-8 | ¥8,820.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Helenalin
描述: Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.
体外活性: After 80 minutes, Helenalin (10 μM; 20-120 minutes) induces complete inhibition of NF-κB DNA binding [1]. Helenalin, the anti-inflammatory and anti-carcinogenic phytochemicals, is an effective inhibitor of periodic Skp2 accumulation which is an F-box protein mediating SCF E3 ligase ubiquitylation and degradation of both CKIs during S phase progression[3].
体内活性: To immature male ICR mice, Helenalin (25 mg/kg; i.p.; 6 to 12 hours) administers, induced a rapid reduction in hepatic glutathione levels[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Helenalin
化合物 T15467 T15467信息由TargetMol中国为您提供,如您想了解更多关于化合物 T15467 T15467报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途