化合物JTE-013 T15629

Product Introduction
Bioactivity


英文名: JTE-013

描述: JTE-013 是一种选择性S1P2拮抗剂。它抑制放射性标记的 S1P 与人和大鼠 S1P2的特异性结合，IC50分别为 17 nM 和 22 nM。

体外活性: JTE-013 is a S1P2 antagonist. JTE-013 (50-200 μM;?1-3 days) decreased cell viability.?JTE-013 shows 4.2% inhibition of S1P3 and does not antagonize S1P1 at concentrations up to 10 μM.?JTE-013 (10-1000 nM;?30 mins) reverses S1P-induced Akt inhibition and inhibits S1P-induced ERK activation.

体内活性: JTE-013（灌胃；每日30 mg/kg，连续14天）能减小肿瘤体积和重量。JTE-013的改良产物AB1化合物，在NB中提高了药效、静脉注射药代动力学、细胞活性及抗肿瘤活性，可能增强了其临床和实验应用性。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (244.92 mM)


关键字: LPL Receptor | Apoptosis | Inhibitor | Lysophospholipid Receptor | JTE013 | JTE-013 | inhibit | JTE 013

相关产品: CCI-007 | Vistusertib | Taurodeoxycholic acid | Prosapogenin A | MK-2206 dihydrochloride | BC-​1258 | ICCB280 | Palomid 529 | Hydroxyurea | Sanguinarine

相关库: ReFRAME Related Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | GPCR Compound Library | Apoptosis Compound Library | NO PAINS Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

化合物JTE-013 T15629信息由TargetMol中国为您提供，如您想了解更多关于化合物JTE-013 T15629报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途