化合物KY1220 T15677
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 292168-79-7 | ¥618.00 | 询底价 |
5 mg | 292168-79-7 | ¥1,180.00 | 询底价 |
100 mg | 292168-79-7 | ¥5,660.00 | 询底价 |
1 mL | 292168-79-7 | ¥1,130.00 | 询底价 |
1 mg | 292168-79-7 | ¥429.00 | 询底价 |
25 mg | 292168-79-7 | ¥2,690.00 | 询底价 |
10 mg | 292168-79-7 | ¥1,580.00 | 询底价 |
50 mg | 292168-79-7 | ¥3,990.00 | 询底价 |
Product Introduction
Bioactivity
英文名: KY1220
描述: KY1220 通过靶向 Wnt/β-连环蛋白通路,使 β-连环蛋白和 Ras 不稳定。 它在 HEK293 报告细胞中的 IC50 为 2.1 μM。
体外活性: KY1220 accelerates the degradation rates of both β-catenin and Ras in SW480 cell lines. KY1220 dose-dependently reduces Wnt3a-CM-induced TOPflash reporter activation and mRNA expression of Wnt target genes CCND1 and MYC in HEK293 cells. Ras destabilization by KY1220 consequently inhibits the activities of both ERK and Akt, which are downstream effectors of Ras in SW480 cells harboring a KRAS mutation. In HEK293 cells, both β-catenin and pan-Ras protein levels are similarly reduced in a dose-dependent manner after treatment with KY1220, whereas the mRNA levels of CTNNB1 (which encodes β-catenin), NRAS, KRAS, and HRAS remain unchanged. K-Ras, which has a critical role in the progression of CRCs, is also destabilized by KY1220 via polyubiquitin-dependent proteasomal degradation. The proliferation and transformation of the HCT15, SW480, D-WT, and D-MT CRC cells are efficiently inhibited after treatment with KY1220.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 100 mg/mL (318.15 mM)
关键字: Beta catenin | inhibit | Wnt | Inhibitor | β-catenin | KY1220 | KY 1220 | KY-1220
相关产品: SSTC3 | 9-Hydroxycanthin-6-one | Windorphen | Pamidronic acid | 2-Methoxystypandrone | FzM1.8 | Gliotoxin | BML-284 | NVP-TNKS656 | Echinacoside
相关库: Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Osteogenesis Compound Library | Anti-Colorectal Cancer Compound Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Obesity Compound Library | Apoptosis Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途