化合物L-NMMA acetate T15697

Product Introduction
Bioactivity


英文名: L-NMMA acetate

描述: L-NMMA acetate (Tilarginine acetate) 是一氧化氮合酶抑制剂, 对其所有亚型均有抑制作用，包括 NOS1，NOS2和 NOS3。与 nNOS (大鼠), eNOS (人), 和 iNOS (小鼠)结合 的 Ki 值分别为0.18，0.4，6 µM。

体外活性: L-NMMA inhibits vasodilator responses to the endothelium-dependent vasodilator ACh but not to the endothelium-independent NP. L-NMMA does not affect isoprenaline-induced relaxation[2]. The inhibitory effect of L-NMMA is unchanged by previous incubation with D-arginine while it is prevented by L-arginine (L-Arg). L-NMMA, starting from 100 μM, produces a concentration-dependent inhibition of the evoked relaxations (2Hz); maximal inhibition at 1 mM averaged about 35%. The Superfusion of L-NMMA decreases arteriolar diameter and causes dose-dependent increases in arteriolar tone. The onset of action of L-NMMA is nearly immediate. NE induced dose-related vasoconstriction that is significantly potentiated by L-NMMA[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 50 mg/mL (201.39 mM)


关键字: Tilarginine Acetate | Tilarginine | Methylarginine | L-NMMA | NOS | Nitric oxide synthases | L NMMA acetate | inhibit | LNMMA acetate | L-NMMA Acetate | NO Synthase | Inhibitor | Methylarginine Acetate

相关产品: MEG hemisulfate | Hydrangenol | 2-Iminobiotin hydrobromide | L-NIO dihydrochloride | 3,4-DAA | 26-Deoxyactein | Pelargonidin chloride | GW274150 phosphate | Aminoguanidine hydrochloride | iNOS-IN-14

相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

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