化合物LDN-212320 T15728

Product Introduction
Bioactivity


英文名: LDN-212320

描述: LDN-212320 (OSU-0212320) 是兴奋性氨基酸转运体 2(EAAT2)/谷氨酸转运体(GLT-1)的激活剂。它通过上调海马和 ACC 星形胶质细胞 GLT-1 的水平来预防伤害性疼痛。

体外活性: LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining [2].

体内活性: After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 16.67 mg/mL (56.81 mM)


关键字: Glutamate transporter 1 | LDN-212320 | inhibit | EAAT2 | LDN/OSU 0212320 | LDN/OSU0212320 | LDN 0212320 | Inhibitor | LDN 212320 | OSU 0212320 | OSU0212320 | LDN0212320 | GLT-1 | Excitatory amino acid transporter 2 | LDN212320

相关产品: Marein | Procyanidin A2 | Dodoviscin A | Glutaminase-IN-1 | T-1095 | SW157765 | lavendustin B | Jujuboside A | Brilliant Yellow | Sennidin B

相关库: Ion Channel Inhibitor Library | Bioactive Compounds Library Max | Metabolism Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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