化合物LP99 T15784

Product Introduction
Bioactivity


英文名: LP99

描述: LP99 是一种表观遗传探针，可破坏 BRD7 和 BRD9 与细胞中染色质的结合。它是一种选择性的 BRD7 和 BRD9 溴结构域抑制剂，对 BRD9 的 Kd 为 99 nM。

体外活性: LP99 (0.8 μM) disrupts BRD9 interactions with chromatin. The addition of LP99 decreased BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose-dependent manner, with cellular IC50 values in the low micromolar range for both histone. LP99 inhibits IL-6 secretion from THP-1 cells in a dose-dependent manner. Cytotoxicity tests in U2OS cells for 24 and 72 hours display the inhibitor to be non-toxic at concentrations of <33 μM .

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (43.6 mM)


关键字: selective | Epigenetic Reader Domain | organocatalysis | cytokine | LP-99 | LP 99 | epigenetics | probe | bromodomain | pro-inflammatory | inhibit | Inhibitor | secretion | LP99 | histones

相关产品: ZL0580 | SR-0813 | ARV-771 | E-7386 | BD-9136 | ZEN-3219 | GSK046 | 3',6-Disinapoylsucrose | GSK6853 | Bromodomain inhibitor-12

相关库: Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | PPI Inhibitor Library | Histone Modification Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途