化合物 T15817 T15817

Product Introduction
Bioactivity


英文名: Eglumegad

描述: Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).

体外活性: In mouse cortical neurons, Eglumegad down-regulates spots 1014, 1822 (hypoxia up-regulated protein 1), 4513 (an isoform of protein disulfide isomerase 3), 6204, 6312, 7306 (26S proteasome non-ATPase regulatory subunit 7) and protein spots 1013 and 6005 (destrin). It also up-regulates spot 6507 (collapsin response mediator protein 1)[2].

体内活性: Eglumegad (15 or 30 mg/kg, i.p.) has no effect on spatial working memory performance in Gria1?/? or WT mice, and it has no effect on rewarded alternation testing with a short inter-trial interval in Gria1?/? and WT mice at a concentration of 30 mg/kg and it decreases spontaneous locomotor activity in wild-type and Gria1?/? mice[1]. Eglumegad (15 mg/kg, i.p.) reduces novelty-induced hyperlocomotion in naive GluA1-KO and pre-handled GluA1-KO males, but not in females and it also significantly reduces the increased c-Fos expression of GluA1-KO males to the level of WT males, but not in females[3]. Eglumegad (10 mg/kg, i.p.) attenuates the immobilization stress-induced increase in BDNF mRNA expression in the rat mPFC[4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 6.33 mg/mL (34.18 mM)


关键字: LY-354740 | Eglumegad | LY 354740

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