化合物 T15831 T15831
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2173582-08-4 | ¥17,200.00 | 询底价 |
100 mg | 2173582-08-4 | ¥29,500.00 | 询底价 |
50 mg | 2173582-08-4 | ¥22,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: M-525
描述: M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL protein-protein interaction inhibitor. It has an Anti-leukemia activity.
体外活性: M-525 (3-300 nM; 24 h) is potent and effective in suppressing the expression of MEIS1 and HOX genes in MV4 11 cells carrying the MLL-AF4 fusion and in MOLM-13 cells carrying the MLL-AF9 fusion. M-525 achieves an IC50 of 3 nM in the MV4 11 cell line and has an IC50 of 2 μM in the HL-60 cell line. It shows high cellular specificity over non-MLL leukemia cells.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: M-525 | M525 | M 525
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途