硫酸特布他林 T1584

Product Introduction
Bioactivity


英文名: Terbutaline Sulfate

描述: Terbutaline Sulfate (Terbutaline hemisulfate) 是一种具有口服活性的 β2-肾上腺素能受体激动剂，是班布特罗的活性代谢物。它可研究哮喘。

激酶实验: Immunoprecipitation-HDAC assays: The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.

体外活性: Terbutaline能够通过支气管,血管和子宫平滑肌的β2受体,产生刺激作用,也能够作用于子宫平滑肌,抑制子宫收缩.

体内活性: 在所有BChE变异体中,Terbutaline能够发挥可逆地竞争性的抑制作用,对于UU（Kd=0.18 mM）,FF（Kd=0.31 mM）和AA纯合子（Kd=3.3 mM）。Terbutaline能够通过选择性作用于β2肾上腺素能发挥支气管扩张作用。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5 mg/mL (18.23 mM)
H2O : 100 mg/mL (364.54 mM)


关键字: macrophages | Terbutaline | Terbutaline Sulfate | Inhibitor | J774 macrophages | Beta Receptor | Terbutaline Hemisulfate | Adrenergic Receptor | asthma | adrenergic receptor agonist | MPK-1 | inhibit

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相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Hypertension Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | GPCR Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Orally Active Compound Library

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