盐酸环胞苷 T1591

Product Introduction
Bioactivity


英文名: Ancitabine hydrochloride

描述: Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。

激酶实验: Human placental aromatase activity: The assay is performed in a total volume of 1 mL at 37 ℃. Unless otherwise noted, the incubation mixture contains 11 nM [4- 14C] androstene-3, 17-dione ([4- 14C]A), 24 mM NADPH (tetrasodium salt Type III), the appropriate concentrations of the desired inhibitor, and 120 μg of microsomal protein. The (4- 14C)A is added as a solution in 1.7% ethanol in 0.05 M potassium phosphate buffer (pH 7.4), so that the final concentration of ethanol does not exceed 0.02% (v/v). The reaction is started by the addition of enzyme and stopped after 20 min by the addition of 7 vol of ethyl acetate. The mixture is agitated on a vortex mixer and centrifuged at 600 g for 5 min. The aqueous phase is re-extracted with 7 vol of ethyl acetate, and the combined extracts are evaporated to dryness using an Evapo-Mix. Over 99% of the radio- active of [4- 14C] added is recovered using this extraction system. The residue obtained is dissolved in 150 μL acetone, and 100 μL aliquots are chromatographed for 65 min on thin-layer plates precoated with silica gel 60 using ethyl: acetate: isooctane (140:60, v/v; system A) or toluene: chloroform: methanol (70:140:20; system B). The radioactive zones of the plate are located with a Berthold LB 2760 thin-layer scanner. The radioactive estradiol (E2) and estrone (E1) neaks are identified by comparison with authentic standards. The corresponding bonding band of silica gel is transferred to vials containing 10 mL of scintillation fluid, and counted with a 6880 Liquid Scintillation system.

体外活性: 作为一种有效的免疫抑制剂,抗病毒和抗肿瘤剂,Cyclocytidine可用于白血病治疗.其需要用不同的复合注射方法才可发挥最大抑制效果.

体内活性: Cyclocytidine对需要DNA复制和处于有丝分裂快速分裂期的细胞作用最为明显。Cyclocytidine对DNA合成所需的DNA和RNA聚合酶以及核苷酸还原酶有也抑制作用。与人类的脱氧核苷结构相似,Cyclocytidine HCl (Ancitabine)整合到人类的DNA以杀死细胞,是Cytarabine的前体药物。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 10 mg/mL (38.22 mM)
H2O : 40 mg/mL (152.9 mM)


关键字: Cyclo-CMP Hydrochloride | Ancitabine hydrochloride | Ancitabine Hydrochloride | Ancitabine | Autophagy | inhibit | CMV | Inhibitor | Cyclocytidine | Cyclocytidine Hydrochloride | Cytomegalovirus | Cyclo-CMP

相关产品: PU-H71 HCl | Daptomycin | RP-6685 | Gemcitabine hydrochloride | Zoliflodacin | 6-Hydroxy-DOPA | RNA polymerase II-IN-1 | Cytembena | IMT1B | ISOPIMPINELLIN

相关库: Anti-Aging Compound Library | Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Anti-Cancer Drug Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途