去氧氟尿苷 T1600

Product Introduction
Bioactivity


英文名: Doxifluridine

描述: Doxifluridine (AMC 0101) 是一种胸苷磷酸化酶活化剂，对 PC9-DPE2细胞的 IC50为0.62 μM。它是具有抗肿瘤活性的抗肿瘤剂 5-fluorouracil (5-FU) 的氟嘧啶衍生物和口服前药。

体外活性: Doxifluridine suppresses tube formation of HUVEC and vascular endothelial growth factor production by FU-MMT-1 cells. [1] Doxifluridine is converted to 5-FU and subsequently to FdUMP, and the results suggest that Doxifluridine exerts its cytotoxic effects through inhibition of TS and incorporation into RNA. [2] Doxifluridine is a fluoropyrimidine derivative that is activated preferentially in malignant cells by thymidine phosphorylase to form 5-fluorouracil (5-FU). Doxifluridine is developed to improve the therapeutic index of 5-FU and to reduce toxicity, including the immunosuppressive, myelosuppressive, and cardiotoxic effects of 5-FU and other fluorinated pyrimidines. [3]

体内活性: Metronomic Doxifluridine alone significantly suppresses tumor growth compared with the untreated (control) group, while metronomic Doxifluridine in combination with TNP-470 significantly inhibits tumor growth compared with each treatment alone in in FU-MMT-1 xenografts. Doxifluridine in combination with TNP-470 also leads to a significant reduction of intratumoral vascularity. [1] Doxifluridine significantly inhibits the growth of KPL-4 tumors, reduces the tissue levels of IL-6, and alleviates body weight loss in nude mice bearing KPL-4 tumors. [4] Doxifluridine results in a significant reduction in the activity of phenytoin p-hydroxylation in rats. Doxifluridine decreases the elimination rate constant and the total clearance in rats. [5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 45 mg/mL (182.8 mM)
DMSO : 55 mg/mL (223.4 mM)


关键字: Nucleoside Antimetabolite/Analog | Inhibitor | AMC-0101 | Doxifluridine | AMC0101 | inhibit

相关产品: Ganciclovir | N2-Methylguanosine | Clofarabine | 5,6-Dihydro-5-methyluracil | Capecitabine | 5-Ethynyluridine | 2′-O-Methylcytidine | 6-O-Methyl Guanosine | Raltitrexed | Gemcitabine elaidate

相关库: Nucleotide Compound Library | Drug Repurposing Compound Library | Drug-Fragment Library | Anti-Cancer Drug Library | Fluorochemical Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Chemotherapy Drug Library | NO PAINS Compound Library

去氧氟尿苷 T1600信息由TargetMol中国为您提供，如您想了解更多关于去氧氟尿苷 T1600报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途