美登醇 T16016
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 57103-68-1 | ¥662.00 | 询底价 |
500 mg | 57103-68-1 | ¥9,330.00 | 询底价 |
1 mg | 57103-68-1 | ¥289.00 | 询底价 |
200 mg | 57103-68-1 | ¥6,290.00 | 询底价 |
1 mL | 57103-68-1 | ¥823.00 | 询底价 |
10 mg | 57103-68-1 | ¥987.00 | 询底价 |
100 mg | 57103-68-1 | ¥4,480.00 | 询底价 |
50 mg | 57103-68-1 | ¥2,980.00 | 询底价 |
2 mg | 57103-68-1 | ¥397.00 | 询底价 |
25 mg | 57103-68-1 | ¥1,990.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Maytansinol
描述: Maytansinol (Ansamitocin P-0) 在体外抑制微管组装并导致微管分解。它与辐射联用,用于果蝇和人类癌细胞。
体外活性: Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 35 mg/mL (61.94 mM)
关键字: Inhibitor | Ansamitocin P 0 | ADC Cytotoxin | Apoptosis | Ansamitocin P0 | inhibit | Microtubule/Tubulin | ADC Payload | Maytansinol
相关产品: Masitinib | NSC 95397 | Thiamine hydrochloride | CI-1040 | Antitumor agent-113 | Flavokawain B | VPC-70063 | Thrombospondin-1 (1016-1023) (human, bovine, mouse) | Cambinol | RSH-7
相关库: Anti-Cancer Compound Library | Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | Natural Product Library for HTS | Apoptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途