米罗那非 T16079

Product Introduction
Bioactivity


英文名: Mirodenafil

描述: Mirodenafil 是一种磷酸二酯酶5（PDE-5）抑制剂，可用于勃起功能紊乱的研究。

体外活性: The pharmacoki-netics of mirodenafil were not significantly altered by this concurrent administration. Mirodenafil (50 or 100 mg), obviously improved erectile function and was well tolerated in a representative population of Korean men with broad-spectrum ED of various etiologies and severities [1]. Mirodenafil administered with alcohol had a tolerability profile comparable to that of mirodenafil alone [2]. The concurrent administration of mirodenafil with alcohol was not associated with clinically significant hemodynamic changes in these healthy male volunteers in Korea. The coadministration of ketoconazole and rifampicin resulted in significant changes in systemic exposure to mirodenafil, in these healthy Korean male volunteers [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.5 mg/mL (51.72 mM)


关键字: Beta catenin | SK-3530 | Glucocorticoid Receptor | Wnt | Apoptosis | β-catenin | inhibit | systemic sclerosis | NIH3T3 | erectile dysfunction | Alzheimer’s disease | HT-22 cells | SH-SY5Y | MRC-5 cells | fibrosis | Inhibitor | SK 3530 | Mirodenafil | Phosphodiesterase (PDE)

相关产品: Enpp/Carbonic anhydrase-IN-1 | OPC18750 HCl | BW-A 78U | SEP-0372814 | Dazonone | Ensifentrine | CM-675 | Olprinone | Rolipram | Moracin M

相关库: ReFRAME Related Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Human Metabolite Library | Inhibitor Library | Metabolism Compound Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途