异维A酸 T1611

Product Introduction
Bioactivity


英文名: Isotretinoin

描述: Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸，具有潜在的抗肿瘤活性。 它结合并激活核视黄酸受体 (RAR)， 活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物，用于治疗严重的痤疮和某些形式的皮肤、头颈癌。

体外活性: Isotretinoin 直接干扰颅神经嵴细胞的发育。[1] Isotretinoin 通过减少神经嵴细胞与细胞基质的黏附力，选择性地影响神经嵴细胞。[2]

体内活性: Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 1 mg/mL (3.32 mM)
DMSO : 45 mg/mL (149.78 mM)


关键字: Retinoic acid receptors | Retinoid X receptors | orally active | Endogenous Metabolite | anticancer | RAR/RXR | Autophagy | inhibit | vitamin A | severe acne | Isotretinoin | Inhibitor

相关产品: Retinoic acid-d5 | AGN 192870 | CD3254 | BMS 195614 | Tarenflurbil | AGN 194310 | PA452 | WYC-209 | Peretinoin | AC-55649

相关库: Human Endogenous Metabolite Library | Drug Repurposing Compound Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Drug Library | Anti-Lung Cancer Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Anti-Fibrosis Compound Library | Anti-infective Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途