化合物N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride T16169

Product Introduction
Bioactivity


英文名: N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride

描述: N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) 是胰蛋白酶样蛋白酶的抑制剂。 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 对 IFN-γ 活性具有抑制作用。

体外活性: A lower concentration of anti-Fas (10 ng/mL) is used to examine the interaction among the three effectors simultaneously, that is, anti-Fas, TLCK, and IFN-γ. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (50 μM) exhibits a small decrease in cell viability. Beyond 50 μM, a dose-dependent decrease in cell viability is observed. IFN-γ slightly reduces cell viability on its own. The addition of anti-Fas (10 ng/mL) results in a slight decrease in cell survival, which is enhanced more than additively in the presence of TLCK, most prominently between 50 and 100 μM. Upon addition of both anti-Fas and IFN-γ, a decrease (≈46%) in cell viability is observed. Moreover, the decrease in cell survival is further enhanced by the addition of higher concentrations of TLCK, 25 μM, and more[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 95 mg/mL(257.24 mM)
DMSO : 245 mg/mL (663.40 mM)


关键字: Inhibitor | inhibit | N alpha Tosyl L lysine chloromethyl ketone hydrochloride | NalphaTosylLlysine chloromethyl ketone hydrochloride

相关产品: MG-132 | Proteasome β2c/i-IN-1 | Marizomib | Puromycin aminonucleoside | Nateglinide | Tomatine | (R)-MG-132 | Delanzomib | Gabexate mesylate | 20S Proteasome activator 1

相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Ubiquitination Compound Library | Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library

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