化合物 Nelonemdaz T16286
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 640290-67-1 | ¥3,730.00 | 询底价 |
50 mg | 640290-67-1 | ¥7,850.00 | 询底价 |
5 mg | 640290-67-1 | ¥1,980.00 | 询底价 |
25 mg | 640290-67-1 | ¥5,930.00 | 询底价 |
100 mg | 640290-67-1 | ¥10,800.00 | 询底价 |
500 mg | 640290-67-1 | ¥21,600.00 | 询底价 |
1 mL | 640290-67-1 | ¥1,730.00 | 询底价 |
1 mg | 640290-67-1 | ¥662.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Nelonemdaz
描述: Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
体外活性: Neu2000 displays apparent neuroprotection against 300 μM N-methyl-D-aspartate (NMDA) at doses as low as 30 μM. Neu2000 inhibits the electrophysiologic response of cultured cortical neurons to 300 μM NMDA in a concentration-dependent manner, indicating that the effect is mediated by a specific action at NMDA receptors. Neu2000 does not protect cortical neurons against α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid- or kainate-mediates excitotoxicity. Neu2000 (100 μM) obviously decreases the maximal NMDA response by 58.31±2.72% (n=5) and the EC50 values of NMDA from 18.88±1.85 to 9.92±0.17 μM (n=5, P<0.05). The Neu2000 dose-response has an IC50 of 35.38±5.94 μM and Hill's coefficient of 0.91 (n=8) [1].
体内活性: Pharmacokinetic analysis reveals that the half-life of Neu2000 is 1.42, 2.14, and 1.79?h following intraperitoneal administration of 10, 25, and 50?mg/kg, respectively. The results of the blood-brain barrier (BBB) test also reveals significant changes in open field locomotion in spinal cord-injured animals treated with Neu2000 compare to vehicle-treated animals. Single (p<0.05) or repeated (p<0.01) Neu2000 treatment causes a decreased swing to stance ratio to compare to vehicle-treated animals. Repeated treatment with Neu2000 induces a 45.6% decrease (p<0.01) in overall lesion volume compared to vehicle treatment, while a single administration of Neu2000 results in a 36.8% decrease (p<0.05) in overall lesion volume. Compare to sham controls, the levels of basal mitochondrial ROS are obviously elevated at 24?h post-surgery in both the vehicle-treated (4.1-fold, p<0.01) and Neu2000-treated (2.9-fold, p<0.01) groups. The Cmax (maximum plasma concentration) is calculated as 3.86, 18.73, and 52.83?μg/mL and the AUC (area under the curve) is determined to be 7.37, 55.15, and 96.77?μg/h/mL at the same respective doses [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 112.5 mg/mL (293.57 mM)
关键字: Nelonemdaz
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途