化合物Cipargamin T16326

Product Introduction
Bioactivity


英文名: Cipargamin

描述: Cipargamin (NITD609) 是一种有效的抗疟药物，对恶性疟原虫的IC50值约为 1 nM。

体外活性: Cipargamin is the most effective inhibitor of early gametocyte development at 50 and 500 nM. Cipargamin displays a dose-dependent inhibiting effect on late gametocyte development. Cipargamin inhibits T. gondii with an MIC90 for tachyzoites of 5 μM and an MIC50 of 1 μM. At the highest concentration tested (10 μM), It has no toxicity to human foreskin fibroblasts (HFFs). Cipargamin shows effective activities against a panel of culture-adapted P. falciparum strains (IC50: 0.5-1.4 nM). Cipargamin is effective as an artesunate with potency in the low nanomolar range (ICIC50 values consistently <10 nM) against all P. falciparum and P. vivax isolates [1][2][3].

体内活性: Cipargamin (100 mg/kg) fully clears P. berghei infection in all treated mice, and partial cure (50%) is achieved with a single oral dose at 30 mg/kg. Cipargamin displays favorable pharmacokinetic properties and shows single-dose cure efficacy in a malaria mouse model [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 0.1 mg/mL (insoluble)
DMSO : 55 mg/mL (140.94 mM)


关键字: inhibit | Cipargamin | KAE-609 | Parasite | NITD-609 | NITD 609 | Inhibitor | KAE 609

相关产品: ABMA | Nanaomycin A | nerolidol | Cowaxanthone B | N-acetyl Dapsone | Dixanthogen | Antimalarial agent 27 | Diloxanide | Ivermectin B1a | Atovaquone

相关库: Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Pediatric Drug Library | Anti-Parasitic Compound Library | NO PAINS Compound Library | Bioactive Compound Library | Anti-Infection Compound Library

化合物Cipargamin T16326信息由TargetMol中国为您提供，如您想了解更多关于化合物Cipargamin T16326报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途