化合物NS3623 T16347

Product Introduction
Bioactivity


英文名: NS3623

描述: NS3623 是 hERG1 (KV11.1)钾通道激活剂，激活IKr 和Ito 电流，具有抗心律失常作用。NS3623也是 hERG1 通道抑制剂。

体外活性: The application of NS3623 (5 μM) greatly increases the size of the tail current confirming previous studies demonstrating this drug increased IKr, in isolated canine cardiomyocytes. NS3623 enhances IKr tail currents (at +50 mV activating pulse) by 60% in normal Mid cells, and 68% in 48 h cultured cells. The effect of NS3623 on IKr recorded from cells kept in culture is evaluated. The magnitude of IKr is greatly decreased compared to freshly isolated cells, after 48 h. Peak IKr tail currents are 0.47 ± 0.08 pA/pF in freshly isolated myocytes and 0.28 ± 0.06 pA/pF in 2-day cultured myocytes. Application of NS3623 increases IKr in cultured Mid cells. Analysis of the current-voltage (I-V) relation of IKr tail current showed that NS3623 increased current density in both 1 day and 2-day cultured Mid cells [3].

体内活性: NS3623 (30 mg/kg; i.v.; lasting for 3 minutes) shortens the corrected QT interval by 25 +/- 4% in anaesthetized guinea pigs.NS3623 (50 mg/kg) immediately reduces the QTcF interval and remains obviously shortened for approximately 30 minutes. NS3623 (50 mg/kg) shortens the QT interval by 30 +/- 6% in conscious guinea pigs [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 9.17 mg/ml (21.46 mM)


关键字: channels | midmyocardial | cardiomyocytes | current | ion | Potassium Channel | canine | Potassium | KcsA | Inhibitor | NS3623 | inhibit | NS 3623 | cells | Antiarrhythmic | effect | NS-3623

相关产品: Tamapin TFA | KT-362 fumarate | ML213 | LY 303511 hydrochloride | Guanfu base A | VU591 | CLP290 | Diazoxide | Wilfordine | Jingzhaotoxin-XII

相关库: Ion Channel Inhibitor Library | Potassium Channel Blocker Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

化合物NS3623 T16347信息由TargetMol中国为您提供，如您想了解更多关于化合物NS3623 T16347报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途