化合物 T16388 T16388

Product Introduction
Bioactivity


英文名: Omidenepag isopropyl

描述: Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as intraocular pressure (IOP)-lowering drug.

体内活性: Omidenepag isopropyl is hydrolyzed in the eye to Omidenepag (OMD), an EP2 receptor agonist, with a significant ocular hypotensive effect in both ocular normotensive and hypertensive animal models[1]. Omidenepag isopropyl also displays significant and dose-dependent IOP-lowering effects at doses of 0.0001%, 0.001%, and 0.01% in ocular normotensive monkeys, with mean maximal IOP reductions of 2.4 ± 0.6, 7.6 ± 1.7, and 13.3 ± 1.2 mm Hg at each tested concentration, respectively. Omidenepag isopropyl at 0.0001%, 0.001%, or 0.01%, Xalatan, or vehicle was topically administered to one eye in ocular normotensive monkeys. IOP changes after drug administration were compared to the predosing baseline value established on day 1.?The significant decreases in IOP for 0.001% and 0.01% OMDI at time 0 of day 7. In ocular hypertensive monkeys finds that Omidenepag isopropyl lowers IOP by increasing both trabecular outflow facility and uveoscleral outflow[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Omidenepag isopropyl

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途