化合物 T16404 T16404
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2222344-98-9 | ¥17,200.00 | 询底价 |
100 mg | 2222344-98-9 | ¥29,500.00 | 询底价 |
50 mg | 2222344-98-9 | ¥22,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: ORIC-101
描述: ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.
体外活性: ORIC-101 (1-1000 nM) dose-dependently decreases the expression of n GR-mediated target gene (IC50s: 17.2 and 21.2 nM, respectively). ORIC-101 displays markedly reduced androgen receptor agonism (EC50, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC50, >10 μM)[1].
体内活性: In OVCAR5 xenograft tumor in cortisol-treated mice, ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) increases the anti-tumor activity in combination with gemcitabine and carboplatin[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: ORIC 101 | ORIC-101 | ORIC101
化合物 T16404 T16404信息由TargetMol中国为您提供,如您想了解更多关于化合物 T16404 T16404报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途