泮考必利 T16433
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 121650-80-4 | ¥4,900.00 | 询底价 |
5 mg | 121650-80-4 | ¥12,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pancopride
描述: Pancopride(LAS 30451) 是一种可口服的新型有长效的选择性 5-HT3 受体拮抗剂,可阻断氮芥和达卡巴嗪诱导的呕吐。
体外活性: Pancopride,一种新型的高效选择性5-HT3受体拮抗剂,经口服和注射途径均能有效抑制由细胞毒药物引起的呕吐。在大鼠大脑皮层膜上,Pancopride对[3H]GR65630标记的5-HT3受体认知位点显示了高亲和力(Ki=0.40 nM)。
体内活性: Pancopride, when administered i.v. 5 minutes before 5-HT challenge, antagonizes 5-HT-induced bradycardia in anaesthetized rats (ID50=0.56 μg/kg) and, when given p.o. 60 minutes before 5-HT challenge, displays similar antagonistic effects (ID50=8.7 μg/kg). A single oral dose of Pancopride (10 μg/kg) significantly inhibits the bradycardic reflex over an 8-hour period. In dogs, Pancopride dose-dependently inhibits the number of vomiting episodes and delays the onset of vomiting induced by cisplatin (ID50=3.6 μg/kg i.v. and 7.1 μg/kg p.o.)[1]. Pancopride not only inhibits vomiting induced by cisplatin in dogs but is also effective in blocking mechloretamine- and dacarbazine-induced emesis without exhibiting any antidopaminergic activity. Additionally, Pancopride stimulates gastric emptying of glass beads in rats (DE50=0.032 mg/kg p.o.). Furthermore, Pancopride (1 mg/kg i.p.) reverses cisplatin-induced slowing of gastric emptying in rats[1].
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: LAS30451 | Pancopride | LAS-30451
相关产品: Promethazine | 5-HT2C agonist-3 free base | Amitifadine hydrochloride | 6-fluoro-DL-Tryptophan | (4E)-SUN9221 | Blonanserin | Rotigotine Hydrochloride | SB-203186 hydrochloride | cis-Urocanic acid | Cerlapirdine
相关库: Membrane Protein-targeted Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途