化合物PD-118057 T16444

Product Introduction
Bioactivity


英文名: PD-118057

描述: PD-118057 是一种有效的乙醚相关(hERG)钾通道激活剂，对 hERG 不显示活性。PD-118057 通过激活 hERG 通道来抑制膜的兴奋性变化。PD-118057预防和逆转 QT 间期延长，是治疗遗传性或获得性长 QT 综合征和充血性心力衰竭的延迟复极的潜在化合物。

体外活性: PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in guinea pig ventricular muscle in acute isolation of guinea pig cardiomyocytes.[1][2]PD-118057 (10 μM) counteracts the current inhibition triggered by Dof and Mox while preserving the unaltered 'hump' shape of the IKr current and exhibiting only a marginal increase in the maximum value of the suppressed current.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90.0 mg/mL (233.0 mM)


关键字: PD118057 | PD 118057 | PD-118057

相关产品: 3-Acetoxy-8(17),13E-labdadien-15-oic acid | Terfenadine | δ-Dendrotoxin | Gut restricted-7 | VU0071063 | Jingzhaotoxin-X | 5-Hydroxydecanoate sodium | SKF-96365 hydrochloride | AUT1 | NS5806

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Tyrosine Kinase Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途