化合物 T16445 T16445

Product Introduction
Bioactivity


英文名: PD 144418

描述: PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for σ1 and σ2 respectively). It shows devoid of any significant affinity for other receptors, ion channels, and enzymes.

体外活性: PD 144418 enhances the reduction in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region, but by itself has no effect in 5-HT and dopamine (DA) synthesis. PD 144418 reverses the N-methyl-D-aspartate (NMDA)-induced increase in cyclic GMP (cGMP) in rat cerebellar slices without affecting the basal levels, showing that σ1 sites may be important in the regulation of glutamine-induced actions [1].

体内活性: PD 144418 has ED50 values is 7.0 mg/kg i.p. PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: PD 144418 | PD144418 | PD-144418

相关产品: WLB-89462 | Sigma-1 receptor antagonist 3 | PD 144418 oxalate | BMY-14802 | S1RA hydrochloride | BMY-14802 hydrochloride | AD186 | KB-5492 FA | PRE-084 hydrochloride | BD-1047 dihydrobromide

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途