化合物Mardepodect T16499

Product Introduction
Bioactivity


英文名: Mardepodect

描述: Mardepodect (PF-2545920) 是一种有效的、口服具有活性的、可透过血脑屏障的、选择性的 PDE10A 抑制剂，IC50=0.37 nM，比作用于其他 PDE 选择性高 1000 多倍。

体内活性: Mardepodect is active in a range of antipsychotic models with the ED50 of 1 mg/kg, antagonizing apomorphine-induced climbing in mice, inhibiting conditioned avoidance responding in both rats and mice, and blocking N-methyl-D-aspartate antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats, while improving baseline sensory gating in mice.Mardepodect induces a dose-dependent increase in striatal cGMP in mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (114.66 mM)


关键字: PF-02545920 | inhibit | PF 2545920 | Inhibitor | Mardepodect | Phosphodiesterase (PDE) | PF2545920

相关产品: BIO-32546 | Diphylline | Adibendan | K-Ras-PDEδ-IN-1 | Autotaxin modulator 1 | IBMX | FCPR03 | Nauclefine | Naproxen etemesil | Theophylline

相关库: Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Metabolism Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途