化合物Pivanex T16545

Product Introduction
Bioactivity


英文名: Pivanex

描述: Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物，是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。

体外活性: Pivanex has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines. Pivanex (200 μM) causes enhancement in the G2-M phase, moderate enhancement in the S phase, and a slight reduction in G0-G1 of the cell cycle. Pivanex (100-500 μM) shows significant anti-proliferation activity in K562 cells. Pivanex (100-500 μM) also increases apoptosis and caspase activity in K562 cells [1][2].

体内活性: Pivanex治疗显著延缓疾病末期的到来，该末期通过体重减轻来定义。Pivanex（200 mg/kg，b.i.d，每日）明显提高了SMN7 SMA小鼠的存活率[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (494.44 mM)


关键字: Chronic | leukemia | muscular | Acute | ALL | atrophy | Inhibitor | lung | Histone deacetylases | NSCLC | myelogenous | lymphoblastic | AN9 | cancer | HDAC | CML | AN 9 | spinal | K562 | Apoptosis | inhibit | Bcr-Abl | Pivalyloxymethyl Butyrate | Pivanex

相关产品: SF5 | (S)-10-Hydroxycamptothecin | Methyl 3,4-dihydroxybenzoate | Picrocrocin | Ciglitazone | Azadirachtin | Serdemetan | Angelicin | SC99 | NS-1619

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | NF-κB Signaling Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Orally Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途