化合物PPADS四钠盐 T16564

Product Introduction
Bioactivity


英文名: PPADS tetrasodium

描述: PPADS tetrasodiuma 是一种有效的 P2X 受体拮抗剂，也是是豚鼠气道平滑肌 Na/Ca²⁺ 交换逆模式的抑制剂，对谷氨酸/NMDA毒性有神经保护作用。PPADS tetrasodiuma 抑制 P2X1、P2X-2、P2X-3 和 P2X-5。

体外活性: In a time- and concentration-dependent manner, PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV)[2].PPADS tetrasodiuma is effective at other native and recombinant P2XRs. Sensitivity to PPADS tetrasodiuma at human P2XRs depends on the subtype and is highest at the hP2X1, -2, -3, -5, and -7Rs with an IC50 of ~1-3 μM and ~30 μM for the hP2X4R[3].

体内活性: In mesangial proliferative glomerulonephritis, PPADS tetrasodiuma (15-60 mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits the proliferation of glomerular mesangial cells (MC) without altering the proliferation of non-MC in vivo[4].

存储条件: keep away from moisture,store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 40 mg/mL (66.74 mM)


关键字: PPADS | PPADS tetrasodium

相关产品: Eliapixant | A 438079 | P2X3 antagonist 38 | Opiranserin hydrochloride | NF023 hexasodium | Aurintricarboxylic acid | BAY-1797 | GSK-1482160 | A-740003 | JNJ-47965567

化合物PPADS四钠盐 T16564信息由TargetMol中国为您提供，如您想了解更多关于化合物PPADS四钠盐 T16564报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途