化合物 T16671 T16671
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 1221964-50-6 | ¥10,600.00 | 询底价 |
100 mg | 1221964-50-6 | ¥17,500.00 | 询底价 |
50 mg | 1221964-50-6 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PS315
描述: PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative of PS48 and is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing displacement of the active site residue Lys111.
体外活性: PS315, binding at the PIF-pocket, induces a displacement of the active site residue Lys111, thereby inhibiting the activity of aPKCs by allosterically affecting the catalytic mechanism of the kinase. Preincubation of U937 cells with 5 μM PS315 inhibits TNF-α caused NF-κB activation by 74%, whereas complete inhibition is observed with 10 μM PS315. The small allosteric inhibitor PS315 and the N-terminal region of aPKC both act directly on the PIF-pocket on-off switch[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: PS315 | PS 315 | PS-315
相关产品: PKC-ε translocation inhibitor peptide | Fasudil hydrochloride | Sotrastaurin | TPPB | Palmitoylcarnitine chloride | R 59-022 hydrochloride | Gardenin A | Verbascoside | Protein kinase inhibitor H-7 dihydrochloride | PKCα (C2-4) inhibitor peptide
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途