化合物 T16676 T16676

Product Introduction
Bioactivity


英文名: PSI-697

描述: PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM).

体外活性: PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1. In vitro, as a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM [1].

体内活性: PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and reduces inflammation in a baboon model of venous thrombosis. PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis. PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to the vehicle, without prolonging bleeding time in a rat venous thrombosis model. PSI-697 (0-50 mg/kg; p.o.) obviously decreases the number of rolling leukocytes by 39% versus vehicle control[1][2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45.8 mg/mL (124.51 mM)


关键字: PSI-697 | PSI 697 | PSI697

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途