维生素E醋酸酯 T16684

Product Introduction
Bioactivity


英文名: Puromycin aminonucleoside

描述: Puromycin aminonucleoside (NSC-3056) 是一种氨基核苷类抗生素，是嘌呤霉素类似物。它可逆抑制二肽基肽酶和胞浆丙氨酸氨基肽酶。它通过以氧化应激依赖性方式调节 ZO-1 来增加足细胞通透性。它诱导细胞凋亡 。

体外活性: Puromycin aminonucleoside -induced podocyte apoptosis is p53 dependent. Puromycin aminonucleoside causes podocyte apoptosis in a time-dependent manner. The IC50 values for PMAT-expressing and vector-transfected cells are 48.9 and 122.1 μM, respectively, suggesting expression of PMAT-enhanced cell sensitivity to Puromycin aminonucleoside. Puromycin aminonucleoside uptake in PMAT-expressing cells is fourfold higher at pH 6.6 than that at pH 7.4. Puromycin aminonucleoside (30 μg/mL) markedly enhances p53 protein levels in podocytes. Puromycin aminonucleoside (250 μM) is toxic to both PMAT-expressing and vector-transfected cells [2][4].

体内活性: Rats given Puromycin aminonucleoside (100 mg/kg, s.c.) gain less weight and their serum creatinine levels are higher than the control rats. The number of podocytes per glomerulus is 95.5±17.6 in the control rats, 90.7 on Day 4 in Puromycin aminonucleoside (8 mg/100 g, i.v.)-treated nephrosis rats. The amount of nephrin per glomerulus in control rats is 1.02±0.11 fmol and those in Puromycin aminonucleoside nephrosis rats are reduced to 0.46±0.06 fmol and 0.35±0.04 fmol on Day 4 and Day 7. The nephrin amount per podocyte is significantly decreased association with the development of proteinuria in Puromycin aminonucleoside nephrosis rats [5][6].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 33.33 mg/mL (113.25 mM)
DMSO : 31 mg/mL(105.33 mM)


关键字: NSC-3056 | Bacterial | Apoptosis | Inhibitor | inhibit | NSC3056 | Aminopeptidase | DPP | Dipeptidyl Peptidase | Antibiotic | Puromycin aminonucleoside

相关产品: TAT-NEP1-40 acetate | Swainsonine | Ulocuplumab | Floxuridine | Bryonolic acid | Deferoxamine | Tolcapone | SR-4835 | PATULIN | SKF-96365 hydrochloride

相关库: Nucleotide Compound Library | HIF-1 Signaling Pathway Compound Library | Bioactive Compounds Library Max | Ubiquitination Compound Library | Inhibitor Library | Metabolism Compound Library | Anti-Bacterial Compound Library | Covalent Inhibitor Library | Anti-Infection Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途