灭藻醌 T16706

Product Introduction
Bioactivity


英文名: Quinoclamine

描述: Quinoclamine 是一种 NF-κB 抑制剂，是一种萘醌衍生物，具有抗肿瘤活性。

体外活性: Quinoclamine induces the differentiation of U-937 cells into macrophage-like cells. Quinoclamine inhibits NF-κB activities in HepG2 cells (IC50: 1.7 μM). Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines. Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis. Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism. Quinoclamine (1-4 μM; 30 minutes ) inhibits endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation [1][2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (240.84 mM)


关键字: Quinoclamine | Nuclear factor-κB | NF-κB | derivative | inhibit | Inhibitor | Nuclear factor-kappaB | naphthoquinone

相关产品: Dehydrodiisoeugenol | Flaconitine | Sakuranetin | Gossypin | Sarsasapogenin | Cyclo(his-pro) | Asatone | 8alpha-Hydroxyhirsutinolide | Glucosamine | Neocryptotanshinone II

相关库: Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Pyroptosis Compound Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Compound Library | Anti-Lung Cancer Compound Library | Antidepressant Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Anti-Pancreatic Cancer Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途