化合物Remibrutinib T16730

Product Introduction
Bioactivity


英文名: Remibrutinib

描述: Remibrutinib 是有效的、口服具有活力的 bruton tyrosine kinase 抑制剂 (IC50:1 nM)，在血液中抑制 BTK 活性的 IC50的值为 0.23 μM。它具有研究慢性荨麻疹的潜力。

体外活性: Remibrutinib inhibits Btk enzymatic activity (IC50: 1 nM in a biochemical enzyme assay). Remibrutinib inhibits Btk enzymatic activity in the blood (IC50: 0.023 μM in vitro B cell activation assay), the whole blood is collected from the abdominal aorta of anesthetized adult male Lewis rats[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (246.29 mM)


关键字: Btk | Inhibitor | inhibit | Bruton tyrosine kinase | Remibrutinib

相关产品: ONO-4059 analog | BMS-986142 | DBt-10 | CP-547632 | Spebrutinib besylate | Syk Inhibitor II dihydrochloride | (±)-Zanubrutinib | Sunvozertinib | JAK3/BTK-IN-1 | Larotinib

相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Highly Selective Inhibitor Library | Orally Active Compound Library | Covalent Inhibitor Library

化合物Remibrutinib T16730信息由TargetMol中国为您提供，如您想了解更多关于化合物Remibrutinib T16730报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途