化合物 T16774 T16774

Product Introduction
Bioactivity


英文名: RO-9187

描述: RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).

体外活性: RO-9187 suppresses RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 or 2′-C-methyl nucleosides. RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. The formation of RO-9187-TP increased in a time- and dose-dependent manner [1].

体内活性: Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of RO-9187 (1.4 and 26 μM ) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with RO-9187 (2000 mg/kg/day)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 7.14 mg/mL (25.12 mM)


关键字: RO 9187 | RO9187 | RO-9187

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途