化合物RWJ-51204 T16811

Product Introduction
Bioactivity


英文名: RWJ-51204

描述: RWJ-51204是选择性的腺苷 A2A 受体拮抗剂， 是 GABA(A) receptor 的部分激动剂（IC50: 0.2-2 nM)。其具有神经保护和改善运动的功效，可用于帕金森疾病的相关研究。

体外活性: RWJ-51204 binds to receptors with Ki ranging from 0.2 to 0.6 nM in the cerebral cortex, cerebellum, or medulla-spinal cord.[1]

体内活性: RWJ-51204 is effective in the conflict test in monkeys (ED50 of approximately 0.5 mg/kg p.o.). RWJ-51204 is orally active in anxiolytic efficacy tests. RWJ-51204 effectively impairs rotarod performance in rats (ED50 = 0.12 mg/kg), and all rats given RWJ-51204 orally at 30 mg/kg exhibit sedation, reduced skeletal muscle tone, and impairment of rotarod performance. [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.99 mg/mL (10 mM)


关键字: RWJ51204 | RWJ-51204 | RWJ 51204

相关产品: SKF89976A hydrochloride | Lorediplon | Imidazenil | (-)-α-Pinene | Isopulegol | Oxiracetam | MmTx2 toxin | E2730 | (-)-Corlumine | Piperazine citrate

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途