化合物 T16870 T16870
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 2004677-13-6 | ¥16,800.00 | 询底价 |
1 mL | 2004677-13-6 | ¥4,930.00 | 询底价 |
2 mg | 2004677-13-6 | ¥2,720.00 | 询底价 |
25 mg | 2004677-13-6 | ¥12,800.00 | 询底价 |
100 mg | 2004677-13-6 | ¥21,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Selgantolimod
描述: Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
体外活性: Selgantolimod induces the cellular immune mediators interleukin (IL)-12 and IL-8, as well as the antiviral cytokines tumor necrosis factor-α and interferon-γ in vitro in human peripheral blood mononuclear cells. Selgantolimod-induced cytokines reduce HBV DNA, RNA, and antigen levels in HBV-infected primary human hepatocytes. Selgantolimod activates natural killer and mucosal-associated invariant T cells, stimulates cluster of differentiation (CD)-8+ T-cell proliferation, and increase IFNγ production while lowering programmed cell death protein 1 expression by HBV-specific CD8+-T cells in vitro in peripheral blood mononuclear cells [1].
体内活性: Selgantolimod (p.o., once-weekly) treatment induces dose-dependent increases in serum IL-12 and IL-1 receptor antagonist (IL-1RA) in cynomolgus monkeys and causes functional cure in the woodchuck model of chronic HBV [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Selgantolimod | GS 9688 | GS9688
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途