化合物SPP-86 T16923

Product Introduction
Bioactivity


英文名: SPP-86

描述: SPP-86 是有效的、选择性的RET 酪氨酸激酶抑制剂，其IC50=8 nM。它能够抑制 MCF7 细胞中 RET 诱导激活的 PI3K/Akt 和 MAPK 信号通路，也能抑制 RET 诱导的 ERα 磷酸化。

体外活性: Administration of SPP-86 (0-10 μM) suppresses RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells. Administration of SPP-86 (0-10 μM) also supppresses MAPK signaling and proliferation in RET/PTC1 expressing TPC1 compared to 8505C or C643 cells [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (360.59 mM)


关键字: SPP 86 | Inhibitor | inhibit | RET | SPP86 | SPP-86

相关产品: Agerafenib hydrochloride | TG101209 | PF 477736 | G-749 | Cabozantinib | TG-89 | Enbezotinib | RPI-1 | SGI-7079 | Pz-1

相关库: Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Apoptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途