化合物SU16f T16947

Product Introduction
Bioactivity


英文名: SU16f

描述: SU16f (3-substituted indolin-2-one 16f) 是一种有效的，选择性 PDGFRβ 抑制剂，对 PDGFRβ，PDGFR1，PDGFR2 的 IC50 分别为 10 nM，140 nM，2.29 μM。SU16f 抑制 PDGFRβ 受体从而可以阻断胃癌来源的间充质干细胞 (GC-MSC) 条件培养基在胃癌细胞增殖和迁移中的促进作用。

体外活性: SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM. SU16f pretreatment causes the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA [1].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (64.69 mM)


关键字: SU16f

相关产品: Sennoside B | 5Z-7-Oxozeaenol | Ilorasertib | Sunitinib Malate | Sorafenib tosylate | JI-101 | Seralutinib | GZD856 | Lenvatinib mesylate | Ponatinib

相关库: PDGFR inhibitor kit | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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