四氢生物蝶呤 T17056

Product Introduction
Bioactivity


英文名: Tetrahydrobiopterin

描述: Tetrahydrobiopterin (BH4) 是芳香族氨基酸羟化酶的辅因子, 也是一氧化氮合酶 (NOS) 的必需辅因子，可用于研究如高血压、高胆固醇血症、糖尿病等内皮功能障碍。

体外活性: Microglia cultures under hyperoxic conditions were supplemented with or without Tetrahydrobiopterin (100 μM). Exposure of microglia to hyperoxia-induced oxidative stress for 24 h showed a significant increase in TSP-1 mRNA expression and protein compared with normoxia (21% O2). Tetrahydrobiopterin supplementation significantly prevents hyperoxia-induced microglial activation and prevents microvascular damage in choroidal explants by reducing Iba-1 and TSP-1 expression.[1]

体内活性: To assess the levels of tetrahydrobiopterin in the retina, three to five retinal pools were collected from WT and HPH-1 mice at postnatal ages 7, 14, and 22 years and evaluated by LC-MS/MS. LC-MS/MS analysis confirmed that the concentration level of tetrahydrobiopterin in the retinal tissue of HPH-1 mice was significantly reduced by approximately 90% compared with WT groups P7, P14, and P22, respectively.[1]

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (165.80 mM)


关键字: BH 4 | Tetrahydrobiopterin | BH-4

相关产品: 6-Dehydrogingerdione | α-Humulene | Flavoglaucin | Diallyl disulfide | 7-Nitroindazole | Nepetoidin B | Sanggenon D | Dexamethasone acetate | Neoechinulin A | Ruscogenin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途