化合物U-46619 T17189
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 56985-40-1 | ¥7,640.00 | 询底价 |
1 mg | 56985-40-1 | ¥1,690.00 | 询底价 |
10 mg | 56985-40-1 | ¥12,700.00 | 询底价 |
Product Introduction
Bioactivity
英文名: U-46619
描述: U-46619是一种有效的TXA2激动剂,是一种血栓素A2类似物(内过氧化物),有诱导肌球蛋白轻链9 (Myl9)基因缺失小鼠主动脉平滑肌(SM)收缩的功能。
体外活性: U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. U-46619 (1 nM-10 μM) causes platelets to shape change and aggregation in a concentration-dependent manner (EC50s: 0.58 μM and 0.013 μM for aggregation and shape change, respectively). U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets. U-46619 (10 nM-10 μM) increases internal Ca2+ concentration and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency [1][2].
体内活性: U-46619 (5 μg/kg; i.v.) 显著地提高了雄性自发性高血压大鼠的血压。[3]
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: U46619 | U 46619 | U-46619
相关产品: Ethynodiol diacetate | Vilaprisan | Desogestrel | Progesterone | Etonogestrel | Estradiol dipropionate | Lynestrenol | Norgestimate | Chlormadinone acetate | 17α-Hydroxyprogesterone
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途