伏环孢素 T17235
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 515814-01-4 | ¥1,390.00 | 询底价 |
50 mg | 515814-01-4 | ¥11,900.00 | 询底价 |
5 mg | 515814-01-4 | ¥3,730.00 | 询底价 |
10 mg | 515814-01-4 | ¥5,990.00 | 询底价 |
100 mg | 515814-01-4 | ¥15,900.00 | 询底价 |
1 mL | 515814-01-4 | ¥7,830.00 | 询底价 |
25 mg | 515814-01-4 | ¥8,890.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Voclosporin
描述: Voclosporin (ISAtx-247) 是一种新型且可口服钙调磷酸酶(CN; PP2B)抑制剂和免疫抑制剂,可用于治疗狼疮性肾炎。
体外活性: Voclosporin (ISATX247) 是一种钙调磷酸酶抑制剂,在体外实验中展现出比环孢素更高的效能。[2]
体内活性: Voclosporin (23.7 mg or 39.5 mg, each twice daily; 265 subjects; 48 weeks) versus placebo in combination with mycophenolate mofetil (2 g/d) and rapidly tapered low-dose oral corticosteroids for induction of remission in LN. CRR at week 24 was achieved by 29 (32.6%) subjects in the low-dose voclosporin group, 24 (27.3%) subjects in the high-dose voclosporin group, and 17 (19.3%) subjects in the placebo group (OR=2.03 for low-dose voclosporin versus placebo). The significantly greater CRR rate in the low-dose voclosporin group persisted at 48 weeks, and CRRs were also significantly more common in the high-dose voclosporin group compared to placebo at 48 weeks. There were more serious adverse events in both voclosporin groups, and more deaths in the low-dose group compared to placebo and high-dose voclosporin groups (11.2%, 1.1%, and 2.3%, respectively). These results suggest that the addition of low-dose voclosporin to mycophenolate mofetil and corticosteroids for induction therapy of active LN results in a superior renal response compared to mycophenolate mofetil and corticosteroids alone, but higher rates of adverse events including death were observed.[3]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45.0 mg/mL (37.1 mM)
关键字: Voclosporin
相关产品: 3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid | M2N12 | SHP099 | DT-061 | N-Stearoylsphingosine | 2-Bromo-4'-hydroxyacetophenone | Rbin-2 | Itacitinib adipate | Salubrinal | (E,E)-RAMB4
相关库: Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途