化合物VU0152100 T17238
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 409351-28-6 | ¥249.00 | 询底价 |
10 mg | 409351-28-6 | ¥927.00 | 询底价 |
2 mg | 409351-28-6 | ¥353.00 | 询底价 |
1 mL | 409351-28-6 | ¥779.00 | 询底价 |
5 mg | 409351-28-6 | ¥575.00 | 询底价 |
100 mg | 409351-28-6 | ¥5,850.00 | 询底价 |
200 mg | 409351-28-6 | ¥7,750.00 | 询底价 |
25 mg | 409351-28-6 | ¥1,760.00 | 询底价 |
500 mg | 409351-28-6 | ¥9,800.00 | 询底价 |
50 mg | 409351-28-6 | ¥3,350.00 | 询底价 |
Product Introduction
Bioactivity
英文名: VU0152100
描述: VU0152100 是一种选择性 M4 mAChR 变构增强剂,EC50为 380 ± 93 nM。
体外活性: VU0152100 was selective for M4 relative to M1, M2, M3, and M5. VU0152100 dose-dependently potentiated the response to an EC20 concentration of ACh (EC50: 1.9 ± 0.2 μM) and increased the maximal response to ACh to approximately 130%. VU0152100 (10 μM) also increased the potency of ACh to induce GIRK-mediated thallium flux, as manifest by a robust (≈30-fold) leftward shift in the ACh CRC from 77 ± 1.2 nM (veh) to 2.35 ± 0.5 nM [1].
体内活性: Systemic administration of VU0152099 and VU0152100 provides robust brain levels of these compounds, the effects of VU0152099 and VU0152100 were evaluated in reversing amphetamine-induced hyperlocomotion in rats using a dose of 56.6 mg/kg i.p. for each compound with a 30-min pretreatment interval [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (131.80 mM)
关键字: VU 152100 | VU 0152100 | Inhibitor | Muscarinic acetylcholine receptor | inhibit | VU0152100 | mAChR | VU-152100 | VU-0152100
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途