盐酸普乐沙福 T1776L

Product Introduction
Bioactivity


英文名: Plerixafor octahydrochloride

描述: Plerixafor octahydrochloride (JM3100 octahydrochloride) 是一种选择性的CXCR4拮抗剂，IC50为 44 nM。Plerixafor 是一种具有造血干细胞动员活性的双环霉素。

细胞实验: Plerixafor is dissolved in DMSO and then diluted with appropriate medium[2]. U87 mg cells are seeded in 96-well plates at the density of 6×103 cells in 200 μL/well and treated with CXCL12, Plerixafor or with peptide R, as described in the previous "Treatments" section. MTT (5 μg/mL) is added at each time point (24, 48, 72 h) during the final 2 h of treatment. After removing cell medium, 100 μL DMSO are added and optical densities measured at 595 nm with a LT-4000MS Microplate Reader. Measurements are made in triplicates from three independent experiments[2].

体外活性: AMD 3100 can inhibit the replication of low-passage clinical HIV-1 isolates (K31, D370, K6/-2, HEM, and JRCSF) in primary T4 lymphocytes (EC50s: 0.16-1.5 ng/ml; EC90s: 0.36-4.7 ng/ml). In primary monocytes, AMD 3100 was active against HIV-1 (K31 and SF-162) at EC50s of 0.28-7.2 ng/mL and EC90s of 0.68-12 ng/mL.

体内活性: Serum drug levels in rabbits given AMD 3100 (10 mg/kg) by the subcutaneous route were determined by a bioassay based on the EC50 of the compound required to inhibit HIV-1 cytopathicity in MT-4 cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Insoluble
H2O : 119.17 mg/mL (150 mM)


关键字: Plerixafor octahydrochloride | AMD 3100 | Virus Protease | SID 791 | SID-791 | JM-3100 Octahydrochloride | AMD-3100 Octahydrochloride | SID-791 Octahydrochloride | JM3100 Octahydrochloride | AMD-3100 | Plerixafor Octahydrochloride | AMD3100 8HCl | AMD3100 | SID791 | HIV | CXC chemokine receptors | SID 791 Octahydrochloride | AMD3100 Octahydrochloride | AMD3100 octahydrochloride | CXCR | Human immunodeficiency virus | inhibit | JM 3100 | Inhibitor | JM-3100 | AMD 3100 Octahydrochloride | JM 3100 Octahydrochloride | Plerixafor | SID791 Octahydrochloride | JM3100

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相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | EMA Approved Drug Library | Autophagy Compound Library

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