化合物AZD2932 T1836

Product Introduction
Bioactivity


英文名: AZD2932

描述: AZD2932是一种多靶点激酶抑制剂，细胞试验中能够抑制 VEGFR2 (IC50:8 nM)，PDGFβ (IC50:4 nM)，PDGFβ (IC50:7 nM) 和 PDGFβ (IC50:9 nM)。

激酶实验: Kinase Assays : In vitro kinase IC50 values are measured using 33P filtration binding assay after 1 hour incubation of kinase, 33P-ATP, Ibrutinib, and substrate [0.2 mg/mL poly(EY)(4:1]. Assays are performed at Reaction Biology.

体外活性: 在C6大鼠胶质瘤模型中,口服AZD2932 (12.5 or 50 mg/kg, b.i.d.)能够抑制肿瘤生长.在带有非PDGFβ表达肿瘤细胞的异种移植物中,口服AZD2932 (50 mg/kg, b.i.d.),Calu-6肿瘤和LoVo肿瘤达生长被抑制.

体内活性: AZD2932能够抑制PDGFRα和PDGFRβ磷酸化。AZD2932有效抑制多种受体,如VEGFR-2（IC50=8 nM）,PDGFRβ（IC50=4 nM）,Flt-3（IC50=7 nM）和c-Kit（IC50=9 nM）的活性。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 82 mg/mL (183.2 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 5 mg/mL (11.17 mM)


关键字: Platelet-derived growth factor receptor | Inhibitor | VEGFR | c-Kit | Fms like tyrosine kinase 3 | Cluster of differentiation antigen 135 | Vascular endothelial growth factor receptor | FLT3 | SCFR | inhibit | PDGFR | AZD2932 | CD117 | AZD 2932 | AZD-2932 | CD135

相关产品: Protein LMWP | Sakuranetin | CP-673451 | TG 100801 | Delphinidin chloride | Penduletin | Golvatinib | Nintedanib | Decursinol angelate | Ripretinib

相关库: Anti-Prostate Cancer Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Reprogramming Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途