化合物Kobe2602 T1892

Product Introduction
Bioactivity


英文名: Kobe2602

描述: Kobe2602 是 Ras-Raf 相互作用抑制剂，具有抗癌化疗活性。它抑制 H-Ras·GTP 与 c-Raf-1 RBD 结合的Ki 值为 149 μM。

激酶实验: Migration assays: Assays are conducted in wells of a 24-well, 8 μm pore size Transwell plate. A 6.5-mm insert membrane is coated with 0.1 mL COL-I (300 μg/mL in MEGM) and then air dried for 16 hours. The collagen coating is rehydrated for 1 hour in 0.2 mL MEGM. The inner chamber contains MEGM-10% FBS as a chemoattractant. The compounds (10–100 μmol/L) or DMSO (0.1%–1%) are added to both inner and outer chambers. Before plating in the outer chamber, cells (5×104) are coincubated for 20 minutes with the compounds or DMSO in MEGM. Cells are allowed to migrate for 16 to 18 hours. The cells remaining on the top surface of the membrane are removed with a cotton swab. The cells on the bottom surface of the membrane are fixed and stained (0.2% crystal violet). The incorporated dye is extracted with 1% SDS and the A570 is measured.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (119.24 mM)


关键字: H-Ras | Inhibitor | antiproliferative | Kobe-2602 | carcinoma | Kobe 2602 | inhibit | Ras | Kobe2602 | Raf

相关产品: RMC-0331 | CCT241161 | Regorafenib monohydrate | Regorafénib N-oxyde (M2) | B-Raf IN 16 | Raf inhibitor 2 | K-Ras(G12C) inhibitor 9 | BMS-214662 | Vem-L-Cy5 | GDC-0879

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Inhibitor Library | GPCR Compound Library | Anti-Cancer Active Compound Library | PPI Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途