亮黑1 T18928

Product Introduction
Bioactivity


英文名: Brilliant Black BN

描述: Brilliant Black BN (E 151) 是一种偶氮染料和一种食品着色剂。它抑制 EV71 与其细胞脱壳因子亲环蛋白 A 之间的相互作用，是一种很有前途的抗 EV71 感染的抗病毒药物。

体外活性: Brilliant black BN inhibited the infection EV71 -GFP at a concentration of 300 μM. Brilliant black BN exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells (IC50: 10.1 μM). Brilliant black BN is able to inhibit all tested 28 EV71, CVA16, and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 μM to 28.12 μM, whereas its 50% cytotoxic concentration is 1870 μM [2].

体内活性: Brilliant black BN (i.p.; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group. All E151 270 treated mice are completely protected throughout the experiment [2].

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 123 mg/mL (141.75 mM)


关键字: HFMD | HEVs | additive,contagious | HEV | EV71,infection | HRVs | antiviral,food | HRV | Rhinovirus | Enterovirus | E-151 | Brilliant Black BN | inhibit | E151 | Inhibitor | disease

相关产品: LHF-535 | 5,7-Dihydroxychromone | (-)-α-Pinene | NS2B-NS3pro-IN-1 | Lycorine | CDK9-IN-25 | N-Desmethylclozapine | 2-Phenylethanol | SARS-CoV-2 3CLpro-IN-21 | NH125

相关库: Human Metabolite Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途